Lipidomics Research

Lipidomics Mass Spectrometry

Mass Spectrometry Applications

Lipidomics research is made possible by advanced technology that gives investigators the ability to study lipids in complex samples such as plasma, tissue or other biofluids. Lipidomics mass spectrometry can be used to document lipid profiles and reveal lipid alterations that occur in metabolic disorders such as diabetes, obesity, hypertension, stroke and atherosclerosis. Mass spectrometry for lipidomics also facilitates detection of spatial and temporal changes in lipids that occur with disease progression or treatment. Because lipidomics research has the power to identify lipid biomarkers and clarify cellular metabolism at the lipid level, it may ultimately improve drug discovery and provide the foundation for more effective treatments for these often intractable diseases.

AB SCIEX is a pioneer and global leader in the use of lipidomics mass spectrometry for lipidomics research. Our instruments, reagents and workflows help researchers identify and quantify thousands of cellular lipids in complex samples. Our innovative bioinformatics software gives them the power to process massive amounts of lipidomics data in ways that were previously impossible.

AB SCIEX offers a suite of powerful instrumentation, workflows, and software for successful lipidomics research and identification and quantitation of lipid species.

  • The TripleTOFTM 5600 system delivers accurate mass lipid profiling for lipidomics research at high speeds without compromising resolution or sensitivity. Its unique MS/MSALL workflow provides automated collection of all precursors within a desired mass range, fragmentation of selected precursor ions, and a record of all product ions. The result is a three-dimensional map of all lipid precursors and fragments that can be mined retrospectively.
  • The QTRAP® 5500 system and other QTRAP® systems deliver class-specific lipid quantitative measurements through precursor-ion and/or neutral-loss scans as well as  Multiple Reaction Monitoring (MRM) experiements. When used for lipidomics mass spectrometry, the enhanced speed of the QTRAP® 5500 accelerates workflows and increases productivity.
  • Targeted quantitative analysis using fast multiplexed MRM experiments on the TripleTOF or QTRAP system provide definitive sensitivity for quantitation of specific lipid molecules.
  • LipidViewTM Software, with a library of over 25,000 lipid species, identifies and characterizes various lipid molecular compositions by lipid head groups, fatty acid and long chain based characteristic fragments and neutral losses.  Data interpretation can also be followed by advanced statistical tools in MarkerViewTM Software and targeted Lipid Assay quantitation in MultiQuantTM Software.

Acquire all of the information in one experiment using MS/MSALL

With the MS/MSALL workflow on a TripleTOFTM 5600 system, every lipid precursor ion is fragmented sequentially which provides a fragmentation map of all lipid species in the sample.  This powerful profiling technique means that the data can be interogated for specific lipid ions or even lipid-classes post-acquisition.


MS/MSALL: A powerful lipid workflow to acquire all of the information in one experiment

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