LipidView™ Software

Mass Spectrometry Software-LipidView™ Software
Mass Spectrometry Software-LipidView™ Software
Mass Spectrometry Software-LipidView™ Software
Mass Spectrometry Software-LipidView™ Software
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For research use only. Not for use in diagnostic procedures.

LipidView™ Software is a data processing tool for the molecular characterization and quantification of lipid species from electrospray mass spectrometry data. The software enables lipid profiling by searching parent- and fragment-ion masses against a lipid fragment database containing over 25,000 entries and reports a numerical and graphical output for various lipid molecular species, lipid classes, fatty acids, and long chain bases.1 LipidView™ Software streamlines key steps such as automated data processing from template methods, method editing and selection, lipid species identification, comprehensive isotope contribution removal, multiple internal standards-based quantification, visualization and result reporting. Combined with the AB SCIEX QTRAP® or TripleTOF® Systems, this complete hardware and software package offers unique data acquisition strategies coupled with automated data processing for lipid profiling.

Trial software downloads
To download a trial version of the latest version of LipidView™ Software and to obtain license keys, visit our LipidView™ Trial Software Download Registration Site.

    New Features in v1.2:

    • Even more lipid structural information added to the database:
      • More than 50 lipid classes and over 25,000 lipid species represented in a lipid fragments database
      • More than 600 characteristic lipid fragments listed
    • Lipid catalogue and lipid calculator utilities for identification verification
    • Data processing can be accomodated for all AB SCIEX Triple Quad™, QTRAP®, and TripleTOF®  Systems,
      as well as legacy systems, including the QSTAR® System and earlier Triple Quad™ Systems
    • Support of lipid bioinformatics in medium sample throughput
    • Enhanced LC/MS support for method development and data processing
    • Access to qualitative data analysis tools through an integrated link to PeakView® Software
    • Ability to export LipidView™ Software methods to suitable formats for use on other AB SCIEX Systems using the new LipidView™ Method Exporter

    1. Ejsing, C.J., Duchoslav, E., Sampaio, J., E. Simons, K., Thiele, C., Ekroos, K., Bonner, R. and Shevchenko, Anal. Chem. 2006; 78: 6202-1.

    Status: Available Item status information

       

      The LipidView™ Software Catalogue Utility: The LipidView™ Software Catalogue Utility (Figure 1) includes over 25,000 possible lipid species and has information on parent formula, molecular mass, isotope distribution correction factor, charge states, adduct modification, and characteristic fragments for each. In addition, the LipidView™ Software Calculator Utility (not shown) retrieves lipids that correspond to a given m/z and can filter out species with uncommon chain compositions.

      Figure 1: LipidView™ Software Catalogue Utility showing data entry for phosphatidyl ethanolamine-38:4 (PE 38:4).

      LipidView Software Catalogue Utility-figure1 showing data entry for PE 38:4

       

       

       

       

       

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      Identify lipids in four steps: LipidView™ Software is structured around four, simple steps as shown in the top left workflow box in Figure 2. After raw data are loaded into the software, processing settings are assigned. Different processing parameters can be set for each sample to facilitate batch handling. For each selected method, the properties are displayed in the Analysis Method Properties window. After processing samples with the "Find Lipids" function, the data output can be viewed in the Results workspace or through user-defined reports.

      Figure 2: Processing setup window in LipidView™ Software showing separate methods per sample.

      Processing Setup Window in LipidView Software-figure2

       

       

       

       

       

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      Lipid Results Workspace:  The Lipid Results Workspace (Figure 3) has a Numerical Results View (top) and a Profile View (bottom).  In the Numerical View, samples can be evaluated side-by-side for spectra comparison, peak intensity, and peak area calculations. Data in columns can be sorted, allowing for sample filtering, grouping, and data export in .txt format.

      Profile View provides links to basic data entries that are highlighted in the upper numerical table; data expansion in Advanced Profile view enables sample grouping and plotting of all lipid, class-specific, and fatty acid data. Retrieving the raw data in Spectrum View (Figure 4)  allows for spectra to be overlaid, summed, and subtracted, as well as peak-labeling.

      Figure 3: LipidView™ Software Results Workspace.

      LipidView software Results Workspace-figure3

       

       

       

       

       

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      Figure 4: Spectrum View window in LipidView™ Software.

      Spectrum View Window in LipidView™ software-figure4

       

       

       

       

       

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      1. Ejsing, C.J., Duchoslav, E., Sampaio, J., E. Simons, K., Thiele, C., Ekroos, K., Bonner, R. and Shevchenko, Anal. Chem. 2006; 78: 6202-14


      For research use only. Not for use in diagnostic procedures.

      Note: See user's manual or package insert for limited label license, and trademark information.