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- May 20, 2013: AB SCIEX Announces In Vitro Diagnostic Devices CE Marked for Europe With these IVD devices, the company is delivering on its strategy to expand the use of its technology in clinical diagnostics, which is widely deemed a new frontier for mass spectrometry.
- HPLC 2013 HPLC 2013 is an international symposium focusing on the latest developments in high performance liquid chromatography and complementary separation techniques such as capillary electrophoresis and supercritical fluid chromatography.
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LipidView™ Software
LipidView™ Software is a data processing tool for the molecular characterization and quantification of lipid species from electrospray MS data. The software enables lipid profiling by searching parent and fragment ion masses against a lipid fragment database containing over 25,000 entries, and reports a numerical and graphical output for various lipid molecular species, lipid classes, fatty acids and long chain bases*. LipidView™ software streamlines a number of key steps such as automated data processing derived from template methods, method editing and selection, lipid species identification, comprehensive isotope contribution removal, multiple internal standards-based quantification, visualization and result reporting. Combined with the AB SCIEX QTRAP® or TripleTOF® Systems, this complete hardware and software package offers unique data acquisition strategies coupled with automated data processing for lipid profiling.
Trial Software DownloadsTo download a trial version of the latest version of LipidViewTM, and to obtain license keys, visit our LipidView™ Trial Software Download Registration Site
- Even more lipids in the database!
- More than 50 lipid classes and over 25,000 lipid species represented in a lipid fragments database
- More than 600 characteristic lipid fragments listed
- Lipid catalogue, lipid calculator utilities
- Process data from all AB SCIEX Triple Quad™, QTRAP®, and TripleTOF® System,
as well as legacy systems including the QSTAR® and our earlier Triple Quads - Support of lipid bioinformatics in medium sample throughput
- Enhanced LC/MS support for method development and data processing
- Access to qualitative data analysis tools through an integrated link to PeakView® software
- Ability to export LipidView software methods to suitable formats for use on other AB SCIEX Systems using the new LipidView Method Exporter
Status: Available 
The LipidViewTM software Catalogue Utility The LipidView™ software Catalogue Utility (Figure 1) includes over 25,000 possible lipid species and has information on parent formula, molecular mass, isotope distribution correction factor, charge states, adduct modification, and characteristic fragments for each. In addition, the LipidView™ software Calculator utility (not shown) retrieves lipids that correspond to a given m/z and can filter out species with uncommon chain compositions.
Figure 1: LipidView™ software Catalogue Utility showing data entry for PE 38:4
Identify Lipids in 4 Steps LipidViewTM software is structured around four simple steps as shown in the top left Workflow box in Figure 2. Initially, raw data are loaded into the software and then the processing settings are assigned. Different processing parameters can be set for each sample which facilitates the handling of sample batches. For each selected method the properties are displayed in the "Analysis method properties" window. After sample processing using the "Find Lipids" button, the data can be viewed in the Results workspace. Additionally user-defined reports can be generated. Figure 2: Processing Setup Window in LipidView™ software showing separate methods per sample.
Lipid Results Workspace The Lipid Results Workspace (Figure 3) has a Numerical Results View (top) and a Profile View (bottom). In the Numerical View, samples are listed for side-by-side comparisons and peak intensities, peak areas, corrected values, etc are displayed. All of the columns can be sorted, the samples can be filtered and grouped, and all of the data can be exported in a .txt format. The basic Profile View directly links to the entries highlighted upper numerical table and can be expanded into an Advanced Profile view which enables sample grouping and the plotting of all lipids, class-specific, fatty acid data etc. The raw data can be retrieved in the Spectrum view (Figure 4) where lipid peaks can be labeled and spectra can be overlaid, summed and subtracted. Figure 3: LipidView™ software Results Workspace
Figure 4: Spectrum View Window in LipidView™ software
*Ejsing, C.J., Duchoslav, E., Sampaio, J., E. Simons, K., Thiele, C., Ekroos, K., Bonner, R. and Shevchenko, Anal. Chem. 2006, 78, 6202-14 Note: See user's manual or package insert for limited label license, and trademark information. |
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